Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells

The mammalian target of rapamycin (mTOR) signaling pathway efficiently regulates the energy state of cells and maintains tissue homeostasis. Dysregulation of the mTOR pathway has been implicated in several human diseases. Rapamycin is a specific inhibitor of mTOR and pharmacological inhibition of mT...

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Gepubliceerd in:Exp Mol Med
Hoofdauteurs: Park, Ji Hye, Lee, Na Kyoung, Lim, Hye Ji, Ji, Seung taek, Kim, Yeon-Ju, Jang, Woong Bi, Kim, Da Yeon, Kang, Songhwa, Yun, Jisoo, Ha, Jong seong, Kim, Hyungtae, Lee, Dongjun, Baek, Sang Hong, Kwon, Sang-Mo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210934/
https://ncbi.nlm.nih.gov/pubmed/32273566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-020-0374-4
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