Systematically optimized BCMA/CS1 bispecific CAR-T cells robustly control heterogeneous multiple myeloma

Chimeric antigen receptor (CAR)-T cell therapy has shown remarkable clinical efficacy against B-cell malignancies, yet marked vulnerability to antigen escape and tumor relapse exists. Here we report the rational design and optimization of bispecific CAR-T cells with robust activity against heterogen...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Zah, Eugenia, Nam, Eunwoo, Bhuvan, Vinya, Tran, Uyen, Ji, Brenda Y., Gosliner, Stanley B., Wang, Xiuli, Brown, Christine E., Chen, Yvonne Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210316/
https://ncbi.nlm.nih.gov/pubmed/32385241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16160-5
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