Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet–induced obesity

Obesity-associated inflammation and loss of muscle function play critical roles in the development of osteoarthritis (OA); thus, therapies that target muscle tissue may provide novel approaches to restoring metabolic and biomechanical dysfunction associated with obesity. Follistatin (FST), a protein...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Tang, Ruhang, Harasymowicz, Natalia S., Wu, Chia-Lung, Collins, Kelsey H., Choi, Yun-Rak, Oswald, Sara J., Guilak, Farshid
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209997/
https://ncbi.nlm.nih.gov/pubmed/32426485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz7492
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