OR06-02 TBR-760, a Chimeric Somatostatin-Dopamine Compound, Arrests Aggressive Non-Functioning Pituitary Adenoma Growth In Vivo

TBR-760 is a chimeric dopamine (DA)-somatostatin (SST) compound with potent agonist activity at both DA type 2 (D2R; EC(50) 0.064nM) and SST type 2 (SSTR2; EC(50) 1.2nM) receptors. Prior studies have demonstrated that the chimeric DA-SST compounds are more potent and effective than either individual...

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Vydáno v:J Endocr Soc
Hlavní autoři: Halem, Heather A, Hochgeschwender, Ute, Thiagalingam, Arunthi, Culler, Michael D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Neuroendocrinology and Pituitary
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209732/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.895
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