SAT-LB126 Metformin Attenuates Sodium Retention and Blood Pressure in Hypertensive Diabetic Mice by Reducing the Phosphorylation of Renal NCC and Its Association With the Actin Cytoskeleton

Metformin is the first-line drug in the treatment of type 2 diabetes mellitus. The aim of this work was to evaluate the efficacy of metformin treatment in reducing blood pressure and investigate the molecular mechanism using a preclinical animal model. Adult male and female diabetic db/db mice with...

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書目詳細資料
發表在:J Endocr Soc
Main Authors: Gholam, Mohammed F, Waleed, Alina, Tuna, Kubra M, Carson-Marino, Morgan, Chacko, Kevin M, Malik, Zeeshan S, Schramm, Whitney C, Lopez, Juliana V Pena, Alli, Abdel A
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
主題:
Diabetes Mellitus and Glucose Metabolism
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7209095/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2201
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