SAT-450 Essential Role of GATA2 in the Negative Regulation of the Prepro-Thyrotropin-Releasing Hormone Gene by Liganded T3 in the Rat Paraventricular Nucleus

T3 inhibits thyrotropin-releasing hormone (TRH) synthesis in hypothalamic paraventricular nucleus (PVN). Although T3 receptor (TR) β2 is known to mediate the negative regulation of prepro-TRH gene, its molecular mechanism remains unknown. Our previous studies on the T3-dependent negative regulation...

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Detalles Bibliográficos
Publicado en:J Endocr Soc
Autores principales: Kuroda, Go, Sasaki, Shigekazu, Matsushita, Akio, Ohba, Kenji, Sakai, Yuki, Shinkai, Shinsuke, Nakamura, Hiroko, Oki, Yutaka
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Thyroid
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208958/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.762
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