SAT-LB106 Metabolic and Brown Adipose Tissue-Specific Effects of the Novel Non-Steroidal Mineralocorticoid Receptor Antagonist Finerenone in a Mouse Model of Diet-Induced Obesity

In this work we studied the metabolic effects of the novel non-steroidal MR antagonist Finerenone (FIN) in mice fed a high-fat diet (HFD, 60% kcal as fat). We also investigated the signaling pathways underlying the beneficial metabolic effects of MR antagonism. After 3 months of HFD, mice treated wi...

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Vydáno v:J Endocr Soc
Hlavní autoři: Marzolla, Vincenzo, Feraco, Alessandra, Gorini, Stefania, Mammi, Caterina, Marrese, Carmen, Boitani, Carla, Lombes, Marc, Kolkhof, Peter, Ciriolo, Maria Rosa, Armani, Andrea, Caprio, Massimiliano
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Adipose Tissue, Appetite, and Obesity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7208902/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvaa046.2133
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