Combined immunotherapy with nivolumab and ipilimumab with and without local therapy in patients with melanoma brain metastasis: a DeCOG* study in 380 patients

BACKGROUND: Nivolumab combined with ipilimumab have shown activity in melanoma brain metastasis (MBM). However, in most of the clinical trials investigating immunotherapy in this subgroup, patients with symptomatic MBM and/or prior local brain radiotherapy were excluded. We studied the efficacy of n...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Amaral, Teresa, Kiecker, Felix, Schaefer, Sarah, Stege, Henner, Kaehler, Katharina, Terheyden, Patrick, Gesierich, Anja, Gutzmer, Ralf, Haferkamp, Sebastian, Uttikal, Jochen, Berking, Carola, Rafei-Shamsabadi, David, Reinhardt, Lydia, Meier, Friedegund, Karoglan, Ante, Posch, Christian, Gambichler, Thilo, Pfoehler, Claudia, Thoms, Kai, Tietze, Julia, Debus, Dirk, Herbst, Rudolf, Emmert, Steffen, Loquai, Carmen, Hassel, Jessica C, Meiss, Frank, Tueting, Thomas, Heinrich, Vanessa, Eigentler, Thomas, Garbe, Claus, Zimmer, Lisa
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2020
Témata:
Clinical/Translational Cancer Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206917/
https://ncbi.nlm.nih.gov/pubmed/32221017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000333
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