Performance of anti-CD19 chimeric antigen receptor T cells in genetically defined classes of chronic lymphocytic leukemia

BACKGROUND: While achieving prolonged remissions in other B cell-derived malignancies, chimeric antigen receptor (CAR) T cells still underperform when injected into patients with chronic lymphocytic leukemia (CLL). We studied the influence of genetics on CLL response to anti-CD19 CAR T-cell therapy....

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Mancikova, Veronika, Peschelova, Helena, Kozlova, Veronika, Ledererova, Aneta, Ladungova, Adriana, Verner, Jan, Loja, Tomas, Folber, Frantisek, Mayer, Jiri, Pospisilova, Sarka, Smida, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Immune Cell Therapies and Immune Cell Engineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206910/
https://ncbi.nlm.nih.gov/pubmed/32217767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000471
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