Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer

Notch, an essential factor in tissue development and homoeostasis, has been reported to play an oncogenic function in a variety of cancers. Here, we report ubiquitin-specific protease 8 (USP8) as a novel deubiquitylase of Notch1 intracellular domain (NICD). USP8 specifically stabilizes and deubiquit...

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Pubblicato in:Cell Death Differ
Autori principali: Shin, Soyeon, Kim, Kyungeun, Kim, Hwa-Ryeon, Ylaya, Kris, Do, Sung-Im, Hewitt, Stephen M., Park, Hee-Sae, Roe, Jae-Seok, Chung, Joon-Yong, Song, Jaewhan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206187/
https://ncbi.nlm.nih.gov/pubmed/31527799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0419-1
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