Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose

Kruppel-like factor 2 (KLF2) is a positive transcriptional regulator of several endothelial protective molecules, including thrombomodulin (TM), a surface receptor, and endothelial nitric oxide synthase (eNOS), an enzyme that generates nitric oxide (NO). Loss of TM and eNOS causes endothelial dysfun...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sadhukhan, Ratan, Leung, Justin W. C., Garg, Sarthak, Krager, Kimberly J., Savenka, Alena V., Basnakian, Alexei G., Pathak, Rupak
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7206069/
https://ncbi.nlm.nih.gov/pubmed/32382091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64672-3
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