STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia

Insufficient pancreatic β-cell mass or insulin-producing β-cells are implicated in all forms of diabetes mellitus. However, the molecular mechanisms underlying β-cell destruction are complex and not fully defined. Here we observed that activation of STAT3 is intensely and specifically inhibited in β...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Weng, Qinjie, Zhao, Mengting, Zheng, Jiahuan, Yang, Lijun, Xu, Zijie, Zhang, Zhikang, Wang, Jincheng, Wang, Jiajia, Yang, Bo, Richard Lu, Q., Ying, Meidan, He, Qiaojun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205876/
https://ncbi.nlm.nih.gov/pubmed/31097787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0344-3
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