Acid‐sensing ion channel 3 blockade inhibits durovascular and nitric oxide‐mediated trigeminal pain

BACKGROUND AND PURPOSE: There is a major unmet need to develop new therapies for migraine. We have previously demonstrated the therapeutic potential of the acid‐sensing ion channel (ASIC) blockade in migraine, via an ASIC1 mechanism. ASIC3 is expressed in the trigeminal ganglion and its response is...

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Sparad:
Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Holton, Christopher M., Strother, Lauren C., Dripps, Isaac, Pradhan, Amynah A., Goadsby, Peter J., Holland, Philip R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205795/
https://ncbi.nlm.nih.gov/pubmed/31975427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14990
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