Designing Biodegradable Wafers Based on Poly(L-lactide-co-glycolide) and Poly(glycolide-co-ε-caprolactone) for the Prolonged and Local Release of Idarubicin for the Therapy of Glioblastoma Multiforme

PURPOSE: The blood-brain barrier limits the application of idarubicin in the therapy of glioblastoma multiforme. Biodegradable, intracranial wafers with prolonged release may increase therapy efficiency. METHODS: Blank wafers, wafers containing 5% w/w and 10% w/w of idarubicin were formulated by sol...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Turek, Artur, Stoklosa, Katarzyna, Borecka, Aleksandra, Paul-Samojedny, Monika, Kaczmarczyk, Bożena, Marcinkowski, Andrzej, Kasperczyk, Janusz
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205781/
https://ncbi.nlm.nih.gov/pubmed/32382838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-020-02810-2
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