Intercalated cell BKα subunit is required for flow-induced K(+) secretion

BK channels are expressed in intercalated cells (ICs) and principal cells (PCs) in the cortical collecting duct (CCD) of the mammalian kidney and have been proposed to be responsible for flow-induced K(+) secretion (FIKS) and K(+) adaptation. To examine the IC-specific role of BK channels, we genera...

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Publicado en:JCI Insight
Main Authors: Carrisoza-Gaytan, Rolando, Ray, Evan C., Flores, Daniel, Marciszyn, Allison L., Wu, Peng, Liu, Leah, Subramanya, Arohan R., Wang, WenHui, Sheng, Shaohu, Nkashama, Lubika J., Chen, Jingxin, Jackson, Edwin K., Mutchler, Stephanie M., Heja, Szilvia, Kohan, Donald E., Satlin, Lisa M., Kleyman, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205426/
https://ncbi.nlm.nih.gov/pubmed/32255763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130553
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