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Statistical considerations in the design and analysis of non-inferiority trials with binary endpoints in the presence of non-adherence: a simulation study
Protocol non-adherence is common and poses unique challenges in the interpretation of trial outcomes, especially in non-inferiority trials. We performed simulations of a non-inferiority trial with a time-fixed treatment and a binary endpoint in order to: i) explore the impact of various patterns of...
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| Publié dans: | Wellcome Open Res |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
F1000 Research Limited
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7205408/ https://ncbi.nlm.nih.gov/pubmed/32420455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.15636.2 |
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