Vascularized composite allotransplantation combined with costimulation blockade induces mixed chimerism and reveals intrinsic tolerogenic potential

Vascularized composite allotransplantation (VCA) has become a valid therapeutic option to restore form and function after devastating tissue loss. However, the need for high-dose multidrug immunosuppression to maintain allograft survival is still hampering more widespread application of VCA. In this...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Oh, Byoung Chol, Furtmüller, Georg J., Fryer, Madeline L., Guo, Yinan, Messner, Franka, Krapf, Johanna, Schneeberger, Stefan, Cooney, Damon S., Lee, W.P. Andrew, Raimondi, Giorgio, Brandacher, Gerald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205254/
https://ncbi.nlm.nih.gov/pubmed/32271163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128560
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