Inhibition of Matrix Metalloproteinase with BB-94 Protects against Caerulein-Induced Pancreatitis via Modulating Neutrophil and Macrophage Activation

METHODS: AP was induced in Balb/C mice by ten hourly intraperitoneal injections of caerulein (100 μg/kg) and LPS (5 mg/kg). The MMP inhibitor, BB-94 (20 mg/kg) was intraperitoneally administered 30 min before AP induction. Pancreatitis was confirmed by histology and serum amylase and lipase. Express...

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Veröffentlicht in:Gastroenterol Res Pract
Hauptverfasser: Wu, Zengkai, Mulatibieke, Tunike, Niu, Mengya, Li, Bin, Dai, Juanjuan, Ye, Xin, He, Yan, Chen, Congying, Wen, Li, Hu, Guoyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204304/
https://ncbi.nlm.nih.gov/pubmed/32411205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/8903610
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