MECP2 Duplication Causes Aberrant GABA Pathways, Circuits and Behaviors in Transgenic Monkeys: Neural Mappings to Patients with Autism

MECP2 gain-of-function and loss-of-function in genetically engineered monkeys recapitulates typical phenotypes in patients with autism, yet where MECP2 mutation affects the monkey brain and whether/how it relates to autism pathology remain unknown. Here we report a combination of gene–circuit–behavi...

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Vydáno v:J Neurosci
Hlavní autoři: Cai, Dan-Chao, Wang, Zhiwei, Bo, Tingting, Yan, Shengyao, Liu, Yilin, Liu, Zhaowen, Zeljic, Kristina, Chen, Xiaoyu, Zhan, Yafeng, Xu, Xiu, Du, Yasong, Wang, Yingwei, Cang, Jing, Wang, Guang-Zhong, Zhang, Jie, Sun, Qiang, Qiu, Zilong, Ge, Shengjin, Ye, Zheng, Wang, Zheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7204082/
https://ncbi.nlm.nih.gov/pubmed/32269107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2727-19.2020
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