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The contribution of large genomic rearrangements in BRCA1 and BRCA2 to South African familial breast cancer

BACKGROUND: Pathogenic variants that occur in the familial breast cancer genes (BRCA1/2) lead to truncated ineffective proteins in the majority of cases. These variants are mostly represented by small deletions/insertions, nonsense- and splice-site variants, although some larger pathogenic rearrange...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMC Cancer
Prif Awduron: van der Merwe, Nerina C., Oosthuizen, Jaco, Theron, Magdalena, Chong, George, Foulkes, William D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7203887/
https://ncbi.nlm.nih.gov/pubmed/32375709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-06917-y
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