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Congenital myopathy-related mutations in tropomyosin disrupt regulatory function through altered actin affinity and tropomodulin binding
Tropomyosin binds along actin filaments and regulates myosin binding to control muscle contraction. Tropomodulin binds to the pointed end of a filament and regulates actin dynamics, which maintains the length of a thin filament. To define the structural determinants of these tropomyosin functions, w...
Enregistré dans:
| Publié dans: | FEBS J |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7202179/ https://ncbi.nlm.nih.gov/pubmed/30768849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14787 |
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