Chloride intracellular channel 1 cooperates with potassium channel EAG2 to promote medulloblastoma growth

Ion channels represent a large class of drug targets, but their role in brain cancer is underexplored. Here, we identify that chloride intracellular channel 1 (CLIC1) is overexpressed in human central nervous system malignancies, including medulloblastoma, a common pediatric brain cancer. While glob...

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Udgivet i:J Exp Med
Main Authors: Francisco, Michelle A., Wanggou, Siyi, Fan, Jerry J., Dong, Weifan, Chen, Xin, Momin, Ali, Abeysundara, Namal, Min, Hyun-Kee, Chan, Jade, McAdam, Rochelle, Sia, Marian, Pusong, Ronwell J., Liu, Shixuan, Patel, Nish, Ramaswamy, Vijay, Kijima, Noriyuki, Wang, Lu-Yang, Song, Yuanquan, Kafri, Ran, Taylor, Michael D., Li, Xuejun, Huang, Xi
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201926/
https://ncbi.nlm.nih.gov/pubmed/32097463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190971
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