(99m)Tc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans

Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of (99m)Tc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-(99m)Tc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specific...

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Veröffentlicht in:Contrast Media Mol Imaging
Hauptverfasser: Vallejo-Armenta, Paola, Santos-Cuevas, Clara, Soto-Andonaegui, Juan, Villanueva-Pérez, Rosa M., González-Díaz, Jorge I., García-Pérez, Francisco O., Arrellano-Zarate, Angélica, Luna-Gutiérrez, Myrna, Azorín-Vega, Erika, Ocampo-García, Blanca, Ferro-Flores, Guillermina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201577/
https://ncbi.nlm.nih.gov/pubmed/32410920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/2525037
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