Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study

BACKGROUND: North American health authorities recommend 0.4 mg/day folic acid before conception and throughout pregnancy to reduce the risk of neural tube defects. Folic acid is a synthetic form of folate that must be reduced by dihydrofolate reductase and then further metabolized. Recent evidence s...

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Bibliografiske detaljer
Udgivet i:Trials
Main Authors: Cochrane, Kelsey M., Mayer, Chantal, Devlin, Angela M., Elango, Rajavel, Hutcheon, Jennifer A., Karakochuk, Crystal D.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Study Protocol
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201521/
https://ncbi.nlm.nih.gov/pubmed/32370802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-020-04320-3
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