Loss-of-function polymorphism in IL6R reduces risk of JAK2V617F somatic mutation and myeloproliferative neoplasm: A Mendelian randomization study

BACKGROUND: Whether inflammation is independently associated with development of JAK2V617F mutation and myeloproliferative neoplasm is not clear. We tested the hypothesis that a loss-of-function polymorphism in IL6R (marked by rs4537545) reduces risk of JAK2V617F mutation and myeloproliferative neop...

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Dettagli Bibliografici
Pubblicato in:EClinicalMedicine
Autori principali: Pedersen, Kasper Mønsted, Çolak, Yunus, Ellervik, Christina, Hasselbalch, Hans Carl, Bojesen, Stig Egil, Nordestgaard, Børge Grønne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7201035/
https://ncbi.nlm.nih.gov/pubmed/32382712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eclinm.2020.100280
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