MCL-1(Matrix) maintains neuronal survival by enhancing mitochondrial integrity and bioenergetic capacity under stress conditions

Mitochondria play a crucial role in neuronal survival through efficient energy metabolism. In pathological conditions, mitochondrial stress leads to neuronal death, which is regulated by the anti-apoptotic BCL-2 family of proteins. MCL-1 is an anti-apoptotic BCL-2 protein localized to mitochondria e...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Anilkumar, Ujval, Khacho, Mireille, Cuillerier, Alexanne, Harris, Richard, Patten, David A., Bilen, Maria, Iqbal, Mohamed Ariff, Guo, Ding Yuan, Trudeau, Louis-Eric, Park, David S., Harper, Mary-Ellen, Burelle, Yan, Slack, Ruth S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200794/
https://ncbi.nlm.nih.gov/pubmed/32371858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2498-9
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