The polygenic architecture of left ventricular mass mirrors the clinical epidemiology

Left ventricular (LV) mass is a prognostic biomarker for incident heart disease and all-cause mortality. Large-scale genome-wide association studies have identified few SNPs associated with LV mass. We hypothesized that a polygenic discovery approach using LV mass measurements made in a clinical pop...

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Publicado no:Sci Rep
Main Authors: Mosley, Jonathan D., Levinson, Rebecca T., Farber-Eger, Eric, Edwards, Todd L., Hellwege, Jacklyn N., Hung, Adriana M., Giri, Ayush, Shuey, Megan M., Shaffer, Christian M., Shi, Mingjian, Brittain, Evan L., Chung, Wendy K., Kullo, Iftikhar J., Arruda-Olson, Adelaide M., Jarvik, Gail P., Larson, Eric B., Crosslin, David R., Williams, Marc S., Borthwick, Ken M., Hakonarson, Hakon, Denny, Joshua C., Wang, Thomas J., Stein, Charles M., Roden, Dan M., Wells, Quinn S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200691/
https://ncbi.nlm.nih.gov/pubmed/32372017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-64525-z
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