Targeting mitochondrial and cytosolic substrates of TRIT1 isopentenyltransferase: Specificity determinants and tRNA-i(6)A37 profiles

The tRNA isopentenyltransferases (IPTases), which add an isopentenyl group to N(6) of A37 (i(6)A37) of certain tRNAs, are among a minority of enzymes that modify cytosolic and mitochondrial tRNAs. Pathogenic mutations to the human IPTase, TRIT1, that decrease i(6)A37 levels, cause mitochondrial insu...

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Vydáno v:PLoS Genet
Hlavní autoři: Khalique, Abdul, Mattijssen, Sandy, Haddad, Alexander F., Chaudhry, Shereen, Maraia, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7200024/
https://ncbi.nlm.nih.gov/pubmed/32324744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008330
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