Population Pharmacokinetics and Pharmacodynamics Modeling of Torasemide and Furosemide After Oral Repeated Administration in Healthy Dogs

Torasemide is a loop diuretic licensed in dogs for cardiogenic pulmonary oedema. The aim of this pharmacokinetic-pharmacodynamic (PK/PD) study was to define an optimally effective dosage regimen based on preclinical data. In a first study, 5 dogs received once-daily oral torasemide (0, 0.1, 0.2, 0.4...

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Publicat a:Front Vet Sci
Autors principals: Pelligand, Ludovic, Guillot, Emilie, Geneteau, Anne, Guyonnet, Jerome, Magnier, Reynald, Elliott, Jonathan, Peyrou, Mathieu, Jacobs, Matthieu
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Veterinary Science
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199743/
https://ncbi.nlm.nih.gov/pubmed/32411731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fvets.2020.00151
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