IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis

BACKGROUND: The inflammasome adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is involved in immune signaling by bridging the interactions between inflammasome sensors and caspase-1. Strong experimental evidence has shown that ASC(−/−) mice are protected from disease progressi...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Desu, Haritha L., Plastini, Melanie, Illiano, Placido, Bramlett, Helen M., Dietrich, W. Dalton, de Rivero Vaccari, Juan Pablo, Brambilla, Roberta, Keane, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199312/
https://ncbi.nlm.nih.gov/pubmed/32366256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01826-0
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