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Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells

Vaccinia-related kinase 1 (VRK1) is a chromatin-associated Ser-Thr kinase that regulates numerous downstream factors including DNA repair as well as stress factors c-Jun and p53. Both c-Jun and p53 are phosphorylated at Ser63 and Thr18, respectively, in response to low glucose (40 mg/dl of medium) b...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Yokobori, Kosuke, Miyauchi, Yuu, Williams, Jason G., Negishi, Masahiko
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198045/
https://ncbi.nlm.nih.gov/pubmed/32266931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20200498
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