A functional polymorphism in the paired basic amino acid-cleaving enzyme 4 gene confers osteoarthritis risk in a population of Eastern China

Paired basic amino acid-cleaving enzyme 4 (PACE4), a proprotein convertase, is involved in the activation of aggrecanases (ADAMTS-4 and ADAMTS-5) in osteoarthritic and cytokine-stimulated cartilage. Activated aggrecanases cause aggrecan degradation and thus, contribute to osteoarthritis (OA). In thi...

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Dades bibliogràfiques
Publicat a:Genet Mol Biol
Autors principals: He, Jin, Yang, Haoyu, Xu, Zhonghua, Li, Jin, Chen, Gang, Jiang, Lifeng, Wu, Lidong, Zhou, Xindie
Format: Artigo
Idioma:Inglês
Publicat: Sociedade Brasileira de Genética 2020
Matèries:
Human and Medical Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197988/
https://ncbi.nlm.nih.gov/pubmed/32167127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-4685-GMB-2019-0115
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