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Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses

The wild-derived inbred CAST/EiJ mouse, one of eight founder strains in the Collaborative Cross panel, is an exceptional model for studying monkeypox virus (MPXV), an emerging human pathogen, and other orthopoxviruses including vaccinia virus (VACV). Previous studies suggested that the extreme susce...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Earl, Patricia L., Americo, Jeffrey L., Moss, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197867/
https://ncbi.nlm.nih.gov/pubmed/32320436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008505
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