Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice

Sperm–oocyte fusion is a critical event in mammalian fertilization, categorized by three indispensable proteins. Sperm membrane protein IZUMO1 and its counterpart oocyte membrane protein JUNO make a protein complex allowing sperm to interact with the oocyte, and subsequent sperm–oocyte fusion. Oocyt...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Fujihara, Yoshitaka, Lu, Yonggang, Noda, Taichi, Oji, Asami, Larasati, Tamara, Kojima-Kita, Kanako, Yu, Zhifeng, Matzuk, Ryan M., Matzuk, Martin M., Ikawa, Masahito
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196805/
https://ncbi.nlm.nih.gov/pubmed/32295885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917060117
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