Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes

The developing nervous system is remarkably sensitive to environmental signals, including disruptive toxins, such as polybrominated diphenyl ethers (PBDEs). PBDEs are an environmentally pervasive class of brominated flame retardants whose neurodevelopmental toxicity mechanisms remain largely unclear...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Poston, Robert G., Murphy, Lillian, Rejepova, Ayna, Ghaninejad-Esfahani, Mina, Segales, Joshua, Mulligan, Kimberly, Saha, Ramendra N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Developmental Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196656/
https://ncbi.nlm.nih.gov/pubmed/32229587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011138
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