Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection

Chronic infection by hepatitis B virus (HBV) is associated with high risks of liver fibrosis, cirrhosis and hepatocellular carcinoma. In mouse models of HBV persistence, interleukin 21 (IL-21) has been identified as a potent inducer of viral clearance. Strict hepatotropism makes recombinant HBV (rHB...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Shen, Zhongliang, Wu, Jingwen, Gao, Zixiang, Wang, Jingyu, Zhu, Haoxiang, Mao, Richen, Wang, Xuanyi, Zhang, Jiming, Xie, Youhua, Liu, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196313/
https://ncbi.nlm.nih.gov/pubmed/32373234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.44715
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