Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses

Hematopoietic stem cells (HSCs) in adults are believed to be born from hemogenic endothelial cells (HECs) in mid-gestational embryos. Due to the rare and transient nature, the HSC-competent HECs have never been stringently identified and accurately captured, let alone their genuine vascular precurso...

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Udgivet i:Cell Res
Main Authors: Hou, Siyuan, Li, Zongcheng, Zheng, Xiaona, Gao, Yun, Dong, Ji, Ni, Yanli, Wang, Xiaobo, Li, Yunqiao, Ding, Xiaochen, Chang, Zhilin, Li, Shuaili, Hu, Yuqiong, Fan, Xiaoying, Hou, Yu, Wen, Lu, Liu, Bing, Tang, Fuchou, Lan, Yu
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196075/
https://ncbi.nlm.nih.gov/pubmed/32203131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-0300-2
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