Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas

BACKGROUND: Recurrence after radiation therapy is nearly universal for glioblastomas, the most common form of adult brain cancer. The study aims to define clinically pertinent mechanisms underlying this recurrence. METHODS: microRNA (miRNA) profiling was performed using matched pre- and post-radiati...

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Publicado en:EBioMedicine
Autores principales: Ramakrishnan, Valya, Xu, Beibei, Akers, Johnny, Nguyen, Thien, Ma, Jun, Dhawan, Sanjay, Ning, Jianfang, Mao, Ying, Hua, Wei, Kokkoli, Efrosini, Furnari, Frank, Carter, Bob S., Chen, Clark C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Research paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195524/
https://ncbi.nlm.nih.gov/pubmed/32361246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102736
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