Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

The periplasmic chaperone SurA plays a key role in outer membrane protein (OMP) biogenesis. E. coli SurA comprises a core domain and two peptidylprolyl isomerase domains (P1 and P2), but its mechanisms of client binding and chaperone function have remained unclear. Here, we use chemical cross-linkin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Calabrese, Antonio N., Schiffrin, Bob, Watson, Matthew, Karamanos, Theodoros K., Walko, Martin, Humes, Julia R., Horne, Jim E., White, Paul, Wilson, Andrew J., Kalli, Antreas C., Tuma, Roman, Ashcroft, Alison E., Brockwell, David J., Radford, Sheena E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195389/
https://ncbi.nlm.nih.gov/pubmed/32358557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15702-1
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