Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization

The human genome is extensively folded into 3-dimensional organization. However, the detailed 3D chromatin folding structures have not been fully visualized due to the lack of robust and ultra-resolution imaging capability. Here, we report the development of an electron microscopy method that combin...

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Publicado no:Nat Commun
Main Authors: Trzaskoma, Paweł, Ruszczycki, Błażej, Lee, Byoungkoo, Pels, Katarzyna K., Krawczyk, Katarzyna, Bokota, Grzegorz, Szczepankiewicz, Andrzej A., Aaron, Jesse, Walczak, Agnieszka, Śliwińska, Małgorzata A., Magalska, Adriana, Kadlof, Michal, Wolny, Artur, Parteka, Zofia, Arabasz, Sebastian, Kiss-Arabasz, Magdalena, Plewczyński, Dariusz, Ruan, Yijun, Wilczyński, Grzegorz M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195386/
https://ncbi.nlm.nih.gov/pubmed/32358536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15987-2
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