Influence of media composition on recombinant monoclonal IgA1 glycosylation analysed by lectin-based protein microarray and MALDI-MS

Glycosylation of therapeutic glycoproteins significantly affects their physico-chemical properties, bioactivity and immunogenicity. The determination of glycan composition is highly important regarding their development and production. Therefore, there is a demand for analytical techniques enabling...

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Bibliographic Details
Published in:J Biotechnol
Main Authors: Pažitná, Lucia, Nemčovič, Marek, Pakanová, Zuzana, Baráth, Peter, Aliev, Teimur, Dolgikh, Dmitry, Argentova, Victoria, Katrlík, Jaroslav
Format: Artigo
Language:Inglês
Published: Elsevier B.V. 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7194684/
https://ncbi.nlm.nih.gov/pubmed/32298669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiotec.2020.03.009
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