Targeting c-Src Reverses Accelerated GPX-1 mRNA Decay in Chronic Obstructive Pulmonary Disease Airway Epithelial Cells

Enhanced expression of the cellular antioxidant glutathione peroxidase (GPX)-1 prevents cigarette smoke–induced lung inflammation and tissue destruction. Subjects with chronic obstructive pulmonary disease (COPD), however, have decreased airway GPX-1 levels, rendering them more susceptible to diseas...

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Dettagli Bibliografici
Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Dabo, Abdoulaye J., Ezegbunam, Wendy, Wyman, Anne E., Moon, Jane, Railwah, Christopher, Lora, Alnardo, Majka, Susan M., Geraghty, Patrick, Foronjy, Robert F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193784/
https://ncbi.nlm.nih.gov/pubmed/31801023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2019-0177OC
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