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Challenges and strategies for next-generation bispecific antibody-based antitumor therapeutics

Bispecific antibodies (bsAbs) refer to a large family of molecules that recognize two different epitopes or antigens. Although a series of challenges, especially immunogenicity and chain mispairing issues, once hindered the development of bsAbs, they have been gradually overcome with the help of rap...

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Bibliografiske detaljer
Udgivet i:Cell Mol Immunol
Main Authors: Li, Heliang, Er Saw, Phei, Song, Erwei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193592/
https://ncbi.nlm.nih.gov/pubmed/32313210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-0417-8
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