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Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis

Hyperactivation of sterol regulatory element binding protein 1c (SREBP‐1c), which transcriptionally induces expression of enzymes responsible for de novo lipogenesis and triglyceride (TG) formation, is implicated in nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) pathoge...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: Swiatek, Wojciech, Parnell, K. Mark, Nickols, G. Allen, Scharschmidt, Bruce F., Rutter, Jared
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193131/
https://ncbi.nlm.nih.gov/pubmed/32363320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1498
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