BCL-6 suppresses miR-142-3p/5p expression in SLE CD4(+) T cells by modulating histone methylation and acetylation of the miR-142 promoter

The reduced expression of miR-142-3p/5p in CD4(+) T cells of SLE patients caused T cell hyperactivity and B cell hyperstimulation. This study aimed to investigate the mechanisms of regulating miR-142-3p/5p expression in SLE CD4(+) T cells. The BCL-6 expression was significantly increased in SLE CD4(...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Ding, Shu, Zhang, Qing, Luo, Shuangyan, Gao, Lihua, Huang, Jinhua, Lu, Jianyun, Chen, Jing, Zeng, Qinghai, Guo, Aiyuan, Zeng, Jinrong, Lu, Qianjin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192839/
https://ncbi.nlm.nih.gov/pubmed/31431691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0268-3
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