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Microfluidic automated plasmid library enrichment for biosynthetic gene cluster discovery

Microbial biosynthetic gene clusters are a valuable source of bioactive molecules. However, because they typically represent a small fraction of genomic material in most metagenomic samples, it remains challenging to deeply sequence them. We present an approach to isolate and sequence gene clusters...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Xu, Peng, Modavi, Cyrus, Demaree, Benjamin, Twigg, Frederick, Liang, Benjamin, Sun, Chen, Zhang, Wenjun, Abate, Adam R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192590/
https://ncbi.nlm.nih.gov/pubmed/32095820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa131
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