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Adapting Biased Gene Conversion theory to account for intensive GC-content deterioration in the human genome by novel mutations

We examined seventy million well-characterized human mutations, and their impact on G+C-compositional dynamics, in order to understand the formation and maintenance of major genomic nucleotide sequence patterns. Among novel mutations, those that change a strong (S) base pair G:C/C:G to a weak (W) pa...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Paudel, Rajan, Fedorova, Larisa, Fedorov, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192473/
https://ncbi.nlm.nih.gov/pubmed/32353016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232167
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