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Biomonitoring an albumin adduct of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in humans
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed in cooked meats and may be linked to dietary-associated colorectal, prostate and mammary cancers. Genotoxic N-oxidized metabolites of PhIP react with the Cys(34) of albumin (Alb) to form a sulfinamide adduct, a biomarker of the biologi...
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| Publicado no: | Carcinogenesis |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7191085/ https://ncbi.nlm.nih.gov/pubmed/30247550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy125 |
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