Biomonitoring an albumin adduct of the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in humans

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed in cooked meats and may be linked to dietary-associated colorectal, prostate and mammary cancers. Genotoxic N-oxidized metabolites of PhIP react with the Cys(34) of albumin (Alb) to form a sulfinamide adduct, a biomarker of the biologi...

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Vydáno v:Carcinogenesis
Hlavní autoři: Bellamri, Medjda, Wang, Yi, Yonemori, Kim, White, Kami K, Wilkens, Lynne R, Le Marchand, Loïc, Turesky, Robert J
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Cancer Biomarkers and Molecular Epidemiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191085/
https://ncbi.nlm.nih.gov/pubmed/30247550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy125
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