Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying g...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: De Jesus, Dario F., Orime, Kazuki, Kaminska, Dorota, Kimura, Tomohiko, Basile, Giorgio, Wang, Chih-Hao, Haertle, Larissa, Riemens, Renzo, Brown, Natalie K., Hu, Jiang, Männistö, Ville, Silva, Amélia M., Dirice, Ercument, Tseng, Yu-Hua, Haaf, Thomas, Pihlajamäki, Jussi, Kulkarni, Rohit N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190992/
https://ncbi.nlm.nih.gov/pubmed/32250344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127502
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