Live attenuated pertussis vaccine BPZE1 induces a broad antibody response in humans

BACKGROUND: The live attenuated BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in animal models. Here we report on the responses in humans receiving a single intranasal administration of BPZE1. METHODS: We performed multiple assays to dissect the immu...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Lin, Ang, Apostolovic, Danijela, Jahnmatz, Maja, Liang, Frank, Ols, Sebastian, Tecleab, Teghesti, Wu, Chenyan, van Hage, Marianne, Solovay, Ken, Rubin, Keith, Locht, Camille, Thorstensson, Rigmor, Thalen, Marcel, Loré, Karin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190984/
https://ncbi.nlm.nih.gov/pubmed/31945015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135020
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